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molnupiravir

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By *I Two OP   Couple
over a year ago

PDI 12-26th Nov 24

The magic bullet ?

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By *naswingdressWoman
over a year ago

Manchester (she/her)

No. Monotherapy will accelerate mutation.

Helpful, certainly.

I suspect a silver bullet will look something like a vaccine inducing mucosal immunity, in combination with lowered circulation of the virus (and therefore slowing mutation right down).

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By (user no longer on site)
over a year ago


" in combination with lowered circulation of the virus (and therefore slowing mutation right down)."

A little late for that maybe?

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By *ophieslutTV/TS
over a year ago

Central

A multi-pronged approach is probably needed that will target different aspects of prevention, treatments etc, in very different countries, with varying infrastructures around the world. It's fantastic that we have found some really effective tools to help us, including this one

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By *naswingdressWoman
over a year ago

Manchester (she/her)


" in combination with lowered circulation of the virus (and therefore slowing mutation right down).

A little late for that maybe?"

No. The more it circulates the better it has a chance to do. No matter how little or much it spreads. So (numbers for illustration) a virus that's circulated a million times has had less chance to evolve against our immune system than a virus that's circulated a trillion times.

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By (user no longer on site)
over a year ago

EIDD-2801, AKA Molnupiravir, similar drugs in the same class have been shown to produce birth defects [in animals].

It is of use only in the early stage of sars-cov-2 infection. If the covid disease has progressed, it is of no use.

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By *naswingdressWoman
over a year ago

Manchester (she/her)


"EIDD-2801, AKA Molnupiravir, similar drugs in the same class have been shown to produce birth defects [in animals].

It is of use only in the early stage of sars-cov-2 infection. If the covid disease has progressed, it is of no use."

Yes, that's the other issue - severe disease is no longer in the viral phase

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By (user no longer on site)
over a year ago


" in combination with lowered circulation of the virus (and therefore slowing mutation right down).

A little late for that maybe?

No. The more it circulates the better it has a chance to do. No matter how little or much it spreads. So (numbers for illustration) a virus that's circulated a million times has had less chance to evolve against our immune system than a virus that's circulated a trillion times."

I get that.

My point was that it's a little late to stop covid spreading worldwide. That horse bolted a couple of years ago.

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By *naswingdressWoman
over a year ago

Manchester (she/her)


" in combination with lowered circulation of the virus (and therefore slowing mutation right down).

A little late for that maybe?

No. The more it circulates the better it has a chance to do. No matter how little or much it spreads. So (numbers for illustration) a virus that's circulated a million times has had less chance to evolve against our immune system than a virus that's circulated a trillion times.

I get that.

My point was that it's a little late to stop covid spreading worldwide. That horse bolted a couple of years ago."

I get that too, but the more we slow it down, the more chance we have of keeping up therapeutically. It's not a yes/no question - it's a "how hard do you want this to be" question.

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By (user no longer on site)
over a year ago

Not hard enough to ensure the rest of the world has equal access to vaccines.

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By (user no longer on site)
over a year ago


"Not hard enough to ensure the rest of the world has equal access to vaccines."

Depends.

On whether the PTB want to rest of the world to be vaccinated.

Or prefer depopulation.

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By *naswingdressWoman
over a year ago

Manchester (she/her)


"Not hard enough to ensure the rest of the world has equal access to vaccines."

Yeah... Omicron seems to be a lesson no one wants to look at closely, there.

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By (user no longer on site)
over a year ago


"Not hard enough to ensure the rest of the world has equal access to vaccines.

Yeah... Omicron seems to be a lesson no one wants to look at closely, there."

Though ironically some believe it may have resulted in a lessening of the disease. If that proves to be true it may be that nature will be the source of the solution more so than science.

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By *naswingdressWoman
over a year ago

Manchester (she/her)


"Not hard enough to ensure the rest of the world has equal access to vaccines.

Yeah... Omicron seems to be a lesson no one wants to look at closely, there.

Though ironically some believe it may have resulted in a lessening of the disease. If that proves to be true it may be that nature will be the source of the solution more so than science."

I'll believe it when I see it.

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By (user no longer on site)
over a year ago


"Not hard enough to ensure the rest of the world has equal access to vaccines.

Yeah... Omicron seems to be a lesson no one wants to look at closely, there.

Though ironically some believe it may have resulted in a lessening of the disease. If that proves to be true it may be that nature will be the source of the solution more so than science.

I'll believe it when I see it."

Me too. I guess we'll know soon enough...

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By *ob198XaMan
over a year ago

teleford


"Not hard enough to ensure the rest of the world has equal access to vaccines.

Yeah... Omicron seems to be a lesson no one wants to look at closely, there.

Though ironically some believe it may have resulted in a lessening of the disease. If that proves to be true it may be that nature will be the source of the solution more so than science.

I'll believe it when I see it.

Me too. I guess we'll know soon enough..."

No, not soon enough, hence the current push for masks, working from home and boosters...

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By (user no longer on site)
over a year ago


"Not hard enough to ensure the rest of the world has equal access to vaccines.

Yeah... Omicron seems to be a lesson no one wants to look at closely, there.

Though ironically some believe it may have resulted in a lessening of the disease. If that proves to be true it may be that nature will be the source of the solution more so than science.

I'll believe it when I see it.

Me too. I guess we'll know soon enough...

No, not soon enough, hence the current push for masks, working from home and boosters..."

I can't see how any of that's going to achieve much.

Unless immunity kicks in from the boosters at an unusually rapid rate the boosters will be too late to have much of an impact for people getting together for Christmas parties and gatherings.

As for behavioural changes... I'm not seeing much evidence of that.

If there had been a genuine desire to slow prevalence it would have taken another lockdown.

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