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Spike protein and lung damage

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By *heNaturistCouple OP   Couple
over a year ago

crewe

This was from the journal of physiology and we figured it needed it's own thread.

This was the synopsis of the research.

Acute lung injury (ALI) leading to acute respiratory distress syndrome is the major cause of COVID-19 lethality. Cell entry of SARS-CoV-2 occurs via the interaction between its surface spike protein (SP) and angiotensin-converting enzyme-2 (ACE2). It is unknown if the viral spike protein alone is capable of altering lung vascular permeability in the lungs or producing lung injury in vivo. To that end, we intratracheally instilled the S1 subunit of SARS-CoV-2 spike protein (S1SP) in K18-hACE2 transgenic mice that overexpress human ACE2 and examined signs of COVID-19-associated lung injury 72 h later. Controls included K18-hACE2 mice that received saline or the intact SP and wild-type (WT) mice that received S1SP. K18-hACE2 mice instilled with S1SP exhibited a decline in body weight, dramatically increased white blood cells and protein concentrations in bronchoalveolar lavage fluid (BALF), upregulation of multiple inflammatory cytokines in BALF and serum, histological evidence of lung injury, and activation of signal transducer and activator of transcription 3 (STAT3) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?B) pathways in the lung. K18-hACE2 mice that received either saline or SP exhibited little or no evidence of lung injury. WT mice that received S1SP exhibited a milder form of COVID-19 symptoms, compared with the K18-hACE2 mice. Furthermore, S1SP, but not SP, decreased cultured human pulmonary microvascular transendothelial resistance (TER) and barrier function. This is the first demonstration of a COVID-19-like response by an essential virus-encoded protein by SARS-CoV-2 in vivo. This model of COVID-19-induced ALI may assist in the investigation of new therapeutic approaches for the management of COVID-19 and other coronaviruses.

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By (user no longer on site)
over a year ago

For those of us non-medical, what does that say/prove in terms of humans contracting covid?

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By *heNaturistCouple OP   Couple
over a year ago

crewe


"For those of us non-medical, what does that say/prove in terms of humans contracting covid?"

It's showing that the spike protein is possibly the thing doing the damage and that it's capable of entering the cells on it's own in genetically modified mice with human like ac2 receptors.

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By (user no longer on site)
over a year ago

As a non medical observer, Besides the vaccine, any other remedys.

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By *ethnmelvCouple
over a year ago

Cardiff


" As a non medical observer, Besides the vaccine, any other remedys."

Full HazChem suite with oxygen respirators, move to an remote Island with all its own resources and no incidence yet of Covid.

The rest is snake oil & potentially worse than doing nothing - basically anything Trump suggested is just bo**ox

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By *an4funMan
over a year ago

london


"For those of us non-medical, what does that say/prove in terms of humans contracting covid?

It's showing that the spike protein is possibly the thing doing the damage and that it's capable of entering the cells on it's own in genetically modified mice with human like ac2 receptors."

Can we go another level down on the laymen's scale?

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By *ophieslutTV/TS
over a year ago

Central

It's interesting now, to be getting this level of granularity in the research. It's really allowing us to understand the virus so well and how it actually does its 'work'.

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By (user no longer on site)
over a year ago

Any chance of a citation? Abstracts alone aren't massively helpful.

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By *adForGood69Couple
over a year ago

plymouth

Lemsip

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By *alandNitaCouple
over a year ago

Scunthorpe


" As a non medical observer, Besides the vaccine, any other remedys."

Just for clarity... the article is talking about the VIRUS'S spike proteins, NOT the vaccine

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By (user no longer on site)
over a year ago

Outstandifold in the wettygrippers

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By (user no longer on site)
over a year ago


" As a non medical observer, Besides the vaccine, any other remedys.

Just for clarity... the article is talking about the VIRUS'S spike proteins, NOT the vaccine "

Good point. The Pfizer mRNA vaccine uses a mutant spike protein, right? Stuck a couple of proline units on the end to prevent uptake into respiratory epithelium I seem to recall.

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By (user no longer on site)
over a year ago

The remote island sounds like the best option.

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By *naswingdressWoman
over a year ago

Manchester (she/her)


" As a non medical observer, Besides the vaccine, any other remedys.

Just for clarity... the article is talking about the VIRUS'S spike proteins, NOT the vaccine "

Even if it's both, I'd rather have less spike protein than more.

I'll take the stuff that isn't made to continually replicate in me - so, the vaccine

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By *ophieslutTV/TS
over a year ago

Central


" As a non medical observer, Besides the vaccine, any other remedys.

Just for clarity... the article is talking about the VIRUS'S spike proteins, NOT the vaccine

Even if it's both, I'd rather have less spike protein than more.

I'll take the stuff that isn't made to continually replicate in me - so, the vaccine "

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By *inky_couple2020Couple
over a year ago

North West


"For those of us non-medical, what does that say/prove in terms of humans contracting covid?

It's showing that the spike protein is possibly the thing doing the damage and that it's capable of entering the cells on it's own in genetically modified mice with human like ac2 receptors.

Can we go another level down on the laymen's scale?"

The spike protein on the SARS-CoV-2 virus causes lung injury by various mechanisms.

That's the absolutely simplest explanation.

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By (user no longer on site)
over a year ago


"For those of us non-medical, what does that say/prove in terms of humans contracting covid?

It's showing that the spike protein is possibly the thing doing the damage and that it's capable of entering the cells on it's own in genetically modified mice with human like ac2 receptors.

Can we go another level down on the laymen's scale?

The spike protein on the SARS-CoV-2 virus causes lung injury by various mechanisms.

That's the absolutely simplest explanation. "
my attempt: they worked out which specific bit of the virus causes the nastiness. Which may help in focussing how to fight it.

Or in fav terms : if you know it's the cock (spike) that causes the pregnancy (lung disease ) you can more easily find ways of protecting against it like condoms.

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By (user no longer on site)
over a year ago

OK in layman therms Say what ever you like .at the end of the day we all have to breathe oxygen. Be It droplets are aerosol,s so tell where its safe to breathe air

( Islands already thought of )

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By (user no longer on site)
over a year ago

Condoms blocked there working .

Lungs blocked you die .

Where's the comparison?

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By *naswingdressWoman
over a year ago

Manchester (she/her)


" OK in layman therms Say what ever you like .at the end of the day we all have to breathe oxygen. Be It droplets are aerosol,s so tell where its safe to breathe air

( Islands already thought of ) "

Certain germs (and other things) can hurt your lungs.

One bit of the Covid germs can hurt your lungs. (It's the bit in all the UK approved vaccines - but the virus is a machine designed to make itself over and over again. The vaccine doesn't have the virus making machine in it)

There is no place anywhere on earth where it is guaranteed that you can breathe and not have stuff that will hurt your lungs.

The vaccine makes it less likely that the stuff in Covid will hurt your lungs (or anything else).

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By *naswingdressWoman
over a year ago

Manchester (she/her)


"Condoms blocked there working .

Lungs blocked you die .

Where's the comparison? "

If we know what causes babies, we can stop unwanted pregnancy.

If we know what causes Covid pneumonia, we can learn how to stop Covid pneumonia.

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By *heNaturistCouple OP   Couple
over a year ago

crewe


" As a non medical observer, Besides the vaccine, any other remedys.

Just for clarity... the article is talking about the VIRUS'S spike proteins, NOT the vaccine "
that's ambiguous to the point where there's little difference between the two.

What the study found is that the spike protein itself has the ability to change shape and squeeze inside the cell causing the damage in some small cases instead of binding on to the receptor.

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By *heNaturistCouple OP   Couple
over a year ago

crewe

The same side effects of the virus crop up in the same ratio of vaccines(although in much smaller proportions) and the common link between the two is the spike protein hence the research to help understand the mechanisms.

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