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mRNA Vaccines , a solution waiting for a problem ?

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By *eddy and legs OP   Couple
over a year ago

the wetlands

mRNA Vaccines were first discussed in the 1980s

The first trials in mice were performed 30 years ago when the possibility of new global viruses were being discussed strategically.

Since the much work has been done to develop the platform in readiness for a virus like we have now.

Having completed most or all of the necessary preclinical trials all that remained was to "code" the system for a real virus.

It took 25 days from the release of the genetic sequence of the novel coronavirus to production of the first vaccine and just over two months for the first human trials by Moderna.

This rapid development isn't a reflection of the untested nature of the system of mRNA Vaccines it was already there, waiting for a use

Much has been published relating to the control and safety of such vaccines

Yes this is oversimplified deliberately but you get the point.

Take the time to research it yourself and ignore those that are scared it will turn them into zombies ready to do anything the government asks

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By *heRazorsEdgeMan
over a year ago

Wales/ All over UK

People always think of genetic manipulation and imagine “Dolly” the sheep or designer babies... when really it could mean the rapid elimination of diseases and inherited conditions.

Science is amazing

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By *hrista BellendWoman
over a year ago

surrounded by twinkly lights

The work they are doing using mrna in cancer cell trials is amazing

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By *ophieslutTV/TS
over a year ago

Central

I keep seeing the '10 years to make a vaccine' trope posted by people who don't work in health care, copied from some anti-Vax fbook group etc.

It ignores the huge levels of background work that paves the way for many of them, such as this one. It also ignores why some others have had delays through their development timelines, such as requirements for funding to be secured, personnel recruitment and the great levels of work involved, approvals etc. It naively ignores the huge importance of this pandemic, the massive financial impact to economies and the large financial returns from being early to market with a successful vaccine.

It's great that mRNA technology is now able to pursue other solutions for us.

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By *eddy and legs OP   Couple
over a year ago

the wetlands


"The work they are doing using mrna in cancer cell trials is amazing "

You should see the work they are doing which can identify cancer susceptibility in unborn children and the concepts of modification to remove these. The sheer speed with which sequenceing can take place is breathtaking.

It's beyond my comprehension and I've worked in labs for 30 years

Lots of ethical issues obviously but absolutely amazing.

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By *hrista BellendWoman
over a year ago

surrounded by twinkly lights


"The work they are doing using mrna in cancer cell trials is amazing

You should see the work they are doing which can identify cancer susceptibility in unborn children and the concepts of modification to remove these. The sheer speed with which sequenceing can take place is breathtaking.

It's beyond my comprehension and I've worked in labs for 30 years

Lots of ethical issues obviously but absolutely amazing."

That is a game changer

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By *moothman2000Man
over a year ago

Leicestershire

I think the most exciting thing is what's yet to come.

The ability to just 'splice' a protein to a ready made carrier opens up massive possibilities.

I think this is also the first time I've seen global cooperation on this scale as well.

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By *inky_couple2020Couple
over a year ago

North West


"The work they are doing using mrna in cancer cell trials is amazing

You should see the work they are doing which can identify cancer susceptibility in unborn children and the concepts of modification to remove these. The sheer speed with which sequenceing can take place is breathtaking.

It's beyond my comprehension and I've worked in labs for 30 years

Lots of ethical issues obviously but absolutely amazing."

Are you referring to CRISPR-Cas9? Brilliant stuff but yes, some serious ethical issues. It would seem our Russian friends are forging ahead with it though. Since CRISPR went mainstream, all the Russian biology students we've had have been applying to Genetics and all cite this sort of work as what they see themselves doing in future.

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By *eddy and legs OP   Couple
over a year ago

the wetlands


"The work they are doing using mrna in cancer cell trials is amazing

You should see the work they are doing which can identify cancer susceptibility in unborn children and the concepts of modification to remove these. The sheer speed with which sequenceing can take place is breathtaking.

It's beyond my comprehension and I've worked in labs for 30 years

Lots of ethical issues obviously but absolutely amazing.

Are you referring to CRISPR-Cas9? Brilliant stuff but yes, some serious ethical issues. It would seem our Russian friends are forging ahead with it though. Since CRISPR went mainstream, all the Russian biology students we've had have been applying to Genetics and all cite this sort of work as what they see themselves doing in future."

I was at the launch of a new analyser about 5 years ago and the lead of the development team showed us some of the confidential trials reports. It was mind blowing stuff even then

I'm out of it now nearly two years thankfully as it was getting very difficult to keep up with the advancing techniques ... Leave it to the youtuber generation they seem to have limitless imagination.

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By *inky_couple2020Couple
over a year ago

North West


"The work they are doing using mrna in cancer cell trials is amazing

You should see the work they are doing which can identify cancer susceptibility in unborn children and the concepts of modification to remove these. The sheer speed with which sequenceing can take place is breathtaking.

It's beyond my comprehension and I've worked in labs for 30 years

Lots of ethical issues obviously but absolutely amazing.

Are you referring to CRISPR-Cas9? Brilliant stuff but yes, some serious ethical issues. It would seem our Russian friends are forging ahead with it though. Since CRISPR went mainstream, all the Russian biology students we've had have been applying to Genetics and all cite this sort of work as what they see themselves doing in future.

I was at the launch of a new analyser about 5 years ago and the lead of the development team showed us some of the confidential trials reports. It was mind blowing stuff even then

I'm out of it now nearly two years thankfully as it was getting very difficult to keep up with the advancing techniques ... Leave it to the youtuber generation they seem to have limitless imagination. "

Francis Mojica should be better recognised for his work. Doudna et.al. did drive forward its application in genome editing but without Mojica's work, they'd never have got that far.

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