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"Its possible but I'm more worried about antibiotics not working on a regular basis, I think any money should be spread out over all the medical research not just on virus's. We look too long at one thing and others get neglected and bang we have another pandemic x" Oh definitely! Antibiotic resistance is here and is terrifying. But imagine if this propels research for broad spectrum Coronavirus antivirals. For example. Or different ways of developing vaccines. The depths of immunological research on this is apparently unlike nothing ever seen before | |||
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"Its possible but I'm more worried about antibiotics not working on a regular basis, I think any money should be spread out over all the medical research not just on virus's. We look too long at one thing and others get neglected and bang we have another pandemic x" Antibiotics are given out way too easily for the most minor infections though. Some people I know will actually convince themselves they have a major infection and bug their doctors until they are given antibacs even when not needed. Simply tightening the restrictions and saving them for legit cases will go a long way towards easing resistance imo | |||
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"Its possible but I'm more worried about antibiotics not working on a regular basis, I think any money should be spread out over all the medical research not just on virus's. We look too long at one thing and others get neglected and bang we have another pandemic x Antibiotics are given out way too easily for the most minor infections though. Some people I know will actually convince themselves they have a major infection and bug their doctors until they are given antibacs even when not needed. Simply tightening the restrictions and saving them for legit cases will go a long way towards easing resistance imo" *antibiotics not antibacs Looks like my English is also not Englishing swing  | |||
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"Its possible but I'm more worried about antibiotics not working on a regular basis, I think any money should be spread out over all the medical research not just on virus's. We look too long at one thing and others get neglected and bang we have another pandemic x Antibiotics are given out way too easily for the most minor infections though. Some people I know will actually convince themselves they have a major infection and bug their doctors until they are given antibacs even when not needed. Simply tightening the restrictions and saving them for legit cases will go a long way towards easing resistance imo *antibiotics not antibacs Looks like my English is also not Englishing swing "
I get annoyed that I get a lecture about antibiotic resistance when I seek medical attention.
I never say "I want antibiotics". I say "I have xyz problem".
If antibiotics are warranted, I want antibiotics. If not, tell me what to do.
If I were pestering you for antibiotics, lecture me about how they're not a cure all etc. | |||
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"I think we've now got a 'template' of how to do this and that's fantastic and shows exactly what mankind is capable of doing if we all pull together against a common threat. Going forward, having a template is always a good starting point. I'm not sure I'd like to see it used against the common cold - I suspect we sometimes we need a little 'kick' to ensure our bodies remember how to fight. Antibiotic resistance has been an issue for a while now and I think that is going to be the next big research area. I know some work has been going on looking at 'old remedies' and that often throws up potential solutions, so there might be some avenues to explore there." If it's possible and the technology/ funding is there, it might be useful to have a vaccine for colds for those with immunosuppression. For that small subset, it might be a game changer. | |||
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"We're potentially entering a new era of vaccine technology, with the USA vaccine entering stage 3 trials. Changes in this way open up more possibilities. Vaccines in part rely on the virus that's countered not mutating away from the morphology that the vaccine attacks. If a vaccine can counter significant mutation of the critical elements of it that it targets, it has greater therapeutic potential, over a longer period. Some diseases are more disabling than others. The common cold, for example, tends not to be very severe, compared to flu and certainly not to covid-19. A severe condition that has huge coverage and impact will likely get a greater focus of investment than a mild disease, with a lower impact profile. It's those key elements generally - new capabilities, disease mutation, impacts on the world and the investment needed to get results, that will influence how things progress. Flu treatment and impact may potentially be about to start a new era. A vaccine has been developed that attacks flu generically. Our current vaccines target a guesstimate of the probable strains that will strike. We may or may not get the predictions correct and we don't know what mutations may occur, for example. We have to repeat vaccinations every year, based on the changes that occur. A universal flu vaccine that could give immunity against all known or future mutations of flu would be a game changer, especially if immunity lasted for a significant period of time. Even if needed annually still, it would reduce the many lives lost as well as potential impacts on working life and business performance. The perfect flu vaccine is probably not the 1 that is scheduled to become available in the next year. It may give broader immunity but not all, or for some novel mutations. But I think it would be better than our current type. It could be what's given for winter 2021. Obviously costs may or may not be acceptable and could limit its availability. It would still need to pass all testing and approvals, as any covid-19 vaccine would too. Our increased computational power might also make development more productive. Any organisation researching and developing vaccines will still need finance and sound abilities to back their projects. We've seen how antibiotics research became under-funded, due to the low returns on investment. That could similarly be an issue facing some vaccine research. " This was a lot of words and I am not sure I understood all of them but thank you for your logic based contribution | |||
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"We're potentially entering a new era of vaccine technology, with the USA vaccine entering stage 3 trials. Changes in this way open up more possibilities. Vaccines in part rely on the virus that's countered not mutating away from the morphology that the vaccine attacks. If a vaccine can counter significant mutation of the critical elements of it that it targets, it has greater therapeutic potential, over a longer period. Some diseases are more disabling than others. The common cold, for example, tends not to be very severe, compared to flu and certainly not to covid-19. A severe condition that has huge coverage and impact will likely get a greater focus of investment than a mild disease, with a lower impact profile. It's those key elements generally - new capabilities, disease mutation, impacts on the world and the investment needed to get results, that will influence how things progress. Flu treatment and impact may potentially be about to start a new era. A vaccine has been developed that attacks flu generically. Our current vaccines target a guesstimate of the probable strains that will strike. We may or may not get the predictions correct and we don't know what mutations may occur, for example. We have to repeat vaccinations every year, based on the changes that occur. A universal flu vaccine that could give immunity against all known or future mutations of flu would be a game changer, especially if immunity lasted for a significant period of time. Even if needed annually still, it would reduce the many lives lost as well as potential impacts on working life and business performance. The perfect flu vaccine is probably not the 1 that is scheduled to become available in the next year. It may give broader immunity but not all, or for some novel mutations. But I think it would be better than our current type. It could be what's given for winter 2021. Obviously costs may or may not be acceptable and could limit its availability. It would still need to pass all testing and approvals, as any covid-19 vaccine would too. Our increased computational power might also make development more productive. Any organisation researching and developing vaccines will still need finance and sound abilities to back their projects. We've seen how antibiotics research became under-funded, due to the low returns on investment. That could similarly be an issue facing some vaccine research. This was a lot of words and I am not sure I understood all of them but thank you for your logic based contribution "Thanks  . I'm unsure if I used much logic but I probably could have said that with far fewer words  | |||
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"I think we've now got a 'template' of how to do this and that's fantastic and shows exactly what mankind is capable of doing if we all pull together against a common threat. Going forward, having a template is always a good starting point. I'm not sure I'd like to see it used against the common cold - I suspect we sometimes we need a little 'kick' to ensure our bodies remember how to fight. Antibiotic resistance has been an issue for a while now and I think that is going to be the next big research area. I know some work has been going on looking at 'old remedies' and that often throws up potential solutions, so there might be some avenues to explore there." I don't think our bodies can ever be entirely clean of the common cold, but at least even if just the vulnerable would be protected its doing some good. I'd like to see the same as the flu vaccine protection for the vulnerable The "old remedies" research is interesting, relearning natures medicinal products is a good avenue to move forward on | |||
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"Unlike anything. I can English good" I had noticed and was somewhat  | |||
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"Unlike anything. I can English good I had noticed and was somewhat "Brain fart | |||
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"If they vaccinate against every known common cold, flu, whatever, will that make our immune systems dormant? Will that leave us vulnerable to goodness knows what in the future?" Our immune systems would still be active as, after having got our immunity from vaccines, we will still get viruses and bacteria trying to infect us every day. | |||
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We are very hopeful that the combined efforts of humanity will usher in a golden age of medical tech over the next decade, from the leaps and bounds in rapid RNA/DNA tests, to preemptive vaccine development based on animal virus reservoir data. We dont doubt that this will surely happen again, but if next time we can test people rapidly and at volume, suppression from the start might just be possible even with delayed onset of symptoms. | |||
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"Sophieslut covers everything very succinctly, but one thing that we keep hoping is that if the RNA vaccines work (moderna, imperial) then we will see a surge in use of that technology which will finally rid us of norovirus and give us glorious puke free winters
We are very hopeful that the combined efforts of humanity will usher in a golden age of medical tech over the next decade, from the leaps and bounds in rapid RNA/DNA tests, to preemptive vaccine development based on animal virus reservoir data. We dont doubt that this will surely happen again, but if next time we can test people rapidly and at volume, suppression from the start might just be possible even with delayed onset of symptoms."I really hope we've learned our lesson and will prepare for the next pandemic. | |||
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" This makes me wonder: do you think that developing a vaccine for COVID-19 would pave the way for doing the same with other coronaviruses like SARS, H1N1 and the ones that cause the common cold? None of them have caused wide scale disruption and death on the same level as covid and so presumably have not received the same amount of research and funding. But if they manage to do what was previously thought impossible might it just be a HYPOTHETICAL scenario that 10 years from now these viruses could be fully eradicated the way smallpox was, or at the very least we could be inoculated against the most common strains periodically, like how the flu jab works? "Just to add and clarify some of the OP's questions above: H1N1 is not a coronavirus but influenza and there is a vaccine for it. There may come a time when we have a vaccine against the common cold but as the OP says and answers their question, the cold virus doesn't cause widespread disruption or death, so focus will always be more on incurable/high mortality (if no intervention) and autoimmune diseases. Eradication of an organism is extremely difficult, we thought we might succeed with polio but we still have 3 countries where transmission happens (and distrust of modern and perceived western influence hinders vaccination). Also, viruses like to mutate, so those that plague us now but only cause minor disruption will not have the same genetic makeup in 10 years. The advent of CRISPR has given us new opportunities, and may one day lead to such advances. Lastly, the pathogens we face in the western world are not high priority. Viruses like lassa, Zika, and others the general population are unaware of, pose concern as ones that could cause future epidemics...without going into that flu pandemics happen every 30-odd years. | |||
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" This makes me wonder: do you think that developing a vaccine for COVID-19 would pave the way for doing the same with other coronaviruses like SARS, H1N1 and the ones that cause the common cold? None of them have caused wide scale disruption and death on the same level as covid and so presumably have not received the same amount of research and funding. But if they manage to do what was previously thought impossible might it just be a HYPOTHETICAL scenario that 10 years from now these viruses could be fully eradicated the way smallpox was, or at the very least we could be inoculated against the most common strains periodically, like how the flu jab works?
Just to add and clarify some of the OP's questions above:
H1N1 is not a coronavirus but influenza and there is a vaccine for it.
There may come a time when we have a vaccine against the common cold but as the OP says and answers their question, the cold virus doesn't cause widespread disruption or death, so focus will always be more on incurable/high mortality (if no intervention) and autoimmune diseases.
Eradication of an organism is extremely difficult, we thought we might succeed with polio but we still have 3 countries where transmission happens (and distrust of modern and perceived western influence hinders vaccination). Also, viruses like to mutate, so those that plague us now but only cause minor disruption will not have the same genetic makeup in 10 years. The advent of CRISPR has given us new opportunities, and may one day lead to such advances.
Lastly, the pathogens we face in the western world are not high priority. Viruses like lassa, Zika, and others the general population are unaware of, pose concern as ones that could cause future epidemics...without going into that flu pandemics happen every 30-odd years. ""Bird flu" lol the clue is in the name, this is what happens when you don't proofread
Yes I understand the mutation part; with the flu jab they pick the strains that they think are going to be most prevalent each year so was thinking something along the lines of that.
And yeah I see little sense in trying to stop the common cold which in the grand scale of things is just a minor annoyance but my thinking was more along the lines of applying what we have learned about this virus to other coronaviruses. | |||
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"Sophieslut covers everything very succinctly, but one thing that we keep hoping is that if the RNA vaccines work (moderna, imperial) then we will see a surge in use of that technology which will finally rid us of norovirus and give us glorious puke free winters
We are very hopeful that the combined efforts of humanity will usher in a golden age of medical tech over the next decade, from the leaps and bounds in rapid RNA/DNA tests, to preemptive vaccine development based on animal virus reservoir data. We dont doubt that this will surely happen again, but if next time we can test people rapidly and at volume, suppression from the start might just be possible even with delayed onset of symptoms."Stressful and tragic time for the world but exciting time for modern science! They do say necessity is the mother of invention... | |||
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