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(Oxford) Vaccine safety.

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By (user no longer on site) OP   
over a year ago

Lots of people, understandably, are concerned that the vaccine (Oxford) is being rushed through and this could affect it's safety. I too have thought of this but have spoken to an old university colleague who did research into vaccine development and explained the steps/progress to me.

Basically 6 steps that normally take years.

1. Initial Exploratory research.

First...Normally MOST important....financial. Is the market large enough to justify the company investing millions in developing a vaccine? (Obviously yes...quick decision there) Funding provided by UK government anyway.

Secondly technical. Find the RNA of the virus. (Expensive and can take time..though modern techniques have helped) The CCP when they finally told the world about the virus had already done this.

Basically most of stage one done before we even knew about the virus.

2. Preclinical trials. These have been completed in the lab and on animals (mainly monkeys/apes as our ckosest relatives. Took a few months. Now done.

3. Clinical trials. 3 parts.

Safety. Looking for adverse effects etc. These were completed on volunteers some time back...I even tried to volunteer but was declined as they were overwhelmed with volunteers. No apparent problems.

Response. Does the vaccine produce the required effect? Results released the other week. Produces both antibodies and T-cells.

Effectiveness.

Large scale double blind tests. Underway in Brazil and South Africa as our infection rate has become too low for statistically reliable results. Could take a few more months.

4. Regulatory re_iew and approval. As many vaccines are normally developed "in secret" to prevent rival pharmas getting hold of stuff pre-patent this only starts late on. Much of it has been ongoing already so should be much quicker.

5. Large Scale Manufacture.

Setting this up is hugely expensive and takes time. The real "risk" here is financial. The UK government and Astra Zeneca have taken the risk in assuming everything else works and have already commenced this.

6. Quality Control

This isn't going to be one of those internet drugs from a shed in India or China. Oxford University and Astra Zeneca know what they are doing.

What I was told certainly reassured me.

I know the "anti-vac" brigade will chio in with the usual cinspiracy nonsense. But I hope this will help reassure those with genuine concerns.

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By *sGivesWoodWoman
over a year ago

ST. AUSTELL, CORNWALL

As long as it isn't mandatory, I have no problem with it.

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By *all me FlikWoman
over a year ago

Galaxy Far Far Away

all good news and fingers crossed it has the desired effect.

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By *mmabluTV/TS
over a year ago

upton wirral

I have volunteered for the trials as all sounds good

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By (user no longer on site)
over a year ago


"As long as it isn't mandatory, I have no problem with it. "

There's already a rising figure of over a quarter of UK people who will refuse this vaccine.

Also Bill Gates has funded 750 million dollars towards this Oxford vaccine.

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By *az080378Woman
over a year ago

Cromer


"As long as it isn't mandatory, I have no problem with it.

There's already a rising figure of over a quarter of UK people who will refuse this vaccine.

Also Bill Gates has funded 750 million dollars towards this Oxford vaccine."

Thank you to Bill Gates then, funding is what's making this possible and hopefully providing a light at the end of a very dark tunnel

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By *andKBCouple
over a year ago

Plymouth


"As long as it isn't mandatory, I have no problem with it. "

I think it will be for some people. Like I'm pretty sure itll be mandatory for me working in health care

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By *ackformore100Man
over a year ago

Tin town


"As long as it isn't mandatory, I have no problem with it.

There's already a rising figure of over a quarter of UK people who will refuse this vaccine.

Also Bill Gates has funded 750 million dollars towards this Oxford vaccine."

So 75 per cent will. That's a great place to start from.

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By (user no longer on site)
over a year ago


"As long as it isn't mandatory, I have no problem with it.

There's already a rising figure of over a quarter of UK people who will refuse this vaccine.

Also Bill Gates has funded 750 million dollars towards this Oxford vaccine.

So 75 per cent will. That's a great place to start from. "

Already down to 73% and falling.

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By (user no longer on site)
over a year ago


"As long as it isn't mandatory, I have no problem with it.

There's already a rising figure of over a quarter of UK people who will refuse this vaccine.

Also Bill Gates has funded 750 million dollars towards this Oxford vaccine.

So 75 per cent will. That's a great place to start from.

Already down to 73% and falling."

Is it being so positive that gets you through the day.

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By *alandNitaCouple
over a year ago

Scunthorpe


"As long as it isn't mandatory, I have no problem with it.

There's already a rising figure of over a quarter of UK people who will refuse this vaccine.

Also Bill Gates has funded 750 million dollars towards this Oxford vaccine."

The conspiracy theories over Bill Gates are hilarious. How can anyone be so evil at to give away millions of dollars to help other people.

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By *az080378Woman
over a year ago

Cromer


"As long as it isn't mandatory, I have no problem with it.

There's already a rising figure of over a quarter of UK people who will refuse this vaccine.

Also Bill Gates has funded 750 million dollars towards this Oxford vaccine.

The conspiracy theories over Bill Gates are hilarious. How can anyone be so evil at to give away millions of dollars to help other people. "

Exactly this, all the conspiracy theories have already been disproven so how anyone can be silly enough to keep going on about them is beyond me!!

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By (user no longer on site) OP   
over a year ago


"As long as it isn't mandatory, I have no problem with it.

There's already a rising figure of over a quarter of UK people who will refuse this vaccine.

Also Bill Gates has funded 750 million dollars towards this Oxford vaccine."

Bill Gates has completely and utterly no link, financial of otherwise to the Oxford Vaccine!

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By *alandNitaCouple
over a year ago

Scunthorpe


"As long as it isn't mandatory, I have no problem with it.

There's already a rising figure of over a quarter of UK people who will refuse this vaccine.

Also Bill Gates has funded 750 million dollars towards this Oxford vaccine.

Bill Gates has completely and utterly no link, financial of otherwise to the Oxford Vaccine!"

His Foundation have pre-purchased millions of doses. But then so have our own government.

Cal

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By *spotpleasurerMan
over a year ago

Norwich

The steps you've described are essentially the same for any drug to be approved and are not unique to vaccines.

Given the huge scale of current worldwide effort, sooner or later Covid vaccines will become available. There are two main unknowns for any of these vaccines

1. How long will the vaccine provide immunity?

At one extreme there are vaccines where one dose gives you lifelong protection. At the other end there are vaccines which need frequent renewal.

2. How well will the vaccine protect against mutant forms of the virus?

Viruses mutate constantly, that's what they do. Any resistance will need to be carefully monitored.

Separately, there's the safety issue as no drug is 100% safe. However, vaccines typically do not have serious side effects compared to many other medicines.

While the clinical trials will give some indication, often the true value or risks of a drug can be determined only after it's approved and used by a lot more people.

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By (user no longer on site)
over a year ago


"As long as it isn't mandatory, I have no problem with it.

There's already a rising figure of over a quarter of UK people who will refuse this vaccine.

Also Bill Gates has funded 750 million dollars towards this Oxford vaccine.

Bill Gates has completely and utterly no link, financial of otherwise to the Oxford Vaccine!"

Absolutely totally true. Bill Gates has no link financially or otherwise to the Oxford vaccine

The $750 million funding doesn't count.

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By (user no longer on site)
over a year ago


"As long as it isn't mandatory, I have no problem with it.

There's already a rising figure of over a quarter of UK people who will refuse this vaccine.

Also Bill Gates has funded 750 million dollars towards this Oxford vaccine.

The conspiracy theories over Bill Gates are hilarious. How can anyone be so evil at to give away millions of dollars to help other people.

Exactly this, all the conspiracy theories have already been disproven so how anyone can be silly enough to keep going on about them is beyond me!!"

The conspiracy theories are hilarious and rubbish, just because Bill Gates was a close associate with fellow eugenist Jeffrey Epstein.

The conspiracy tin hatted nutters tried to make out that Jeffrey Epstein was some sort of child trafficking paedophile.

It caused innocent Jeffrey Epstein to take his own life.

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By *ylonSlutTV/TS
over a year ago

Durham


"As long as it isn't mandatory, I have no problem with it.

There's already a rising figure of over a quarter of UK people who will refuse this vaccine.

Also Bill Gates has funded 750 million dollars towards this Oxford vaccine.

Bill Gates has completely and utterly no link, financial of otherwise to the Oxford Vaccine!

Absolutely totally true. Bill Gates has no link financially or otherwise to the Oxford vaccine

The $750 million funding doesn't count."

The $750 dollars are for manufacturing and distribution not research. The gates foundation have given it so bill gates isn't going to profit from it anymore than the nhs or the british government are.

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By (user no longer on site)
over a year ago


"As long as it isn't mandatory, I have no problem with it.

There's already a rising figure of over a quarter of UK people who will refuse this vaccine.

Also Bill Gates has funded 750 million dollars towards this Oxford vaccine.

Bill Gates has completely and utterly no link, financial of otherwise to the Oxford Vaccine!

Absolutely totally true. Bill Gates has no link financially or otherwise to the Oxford vaccine

The $750 million funding doesn't count.

The $750 dollars are for manufacturing and distribution not research. The gates foundation have given it so bill gates isn't going to profit from it anymore than the nhs or the british government are."

Bill Gates has completely and utterly no link, financial of otherwise to the Oxford Vaccine.

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By *ophieslutTV/TS
over a year ago

Central


"As long as it isn't mandatory, I have no problem with it.

There's already a rising figure of over a quarter of UK people who will refuse this vaccine.

Also Bill Gates has funded 750 million dollars towards this Oxford vaccine.

So 75 per cent will. That's a great place to start from.

Already down to 73% and falling."

So tragic that so many people have such a closed mind, when extensive global research hasn't even been completed yet!

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By (user no longer on site) OP   
over a year ago


"As long as it isn't mandatory, I have no problem with it.

There's already a rising figure of over a quarter of UK people who will refuse this vaccine.

Also Bill Gates has funded 750 million dollars towards this Oxford vaccine.

Bill Gates has completely and utterly no link, financial of otherwise to the Oxford Vaccine!

Absolutely totally true. Bill Gates has no link financially or otherwise to the Oxford vaccine

The $750 million funding doesn't count.

The $750 dollars are for manufacturing and distribution not research. The gates foundation have given it so bill gates isn't going to profit from it anymore than the nhs or the british government are.

Bill Gates has completely and utterly no link, financial of otherwise to the Oxford Vaccine.

"

Just as I have no link, financially or otherwise to Weetabix. But I bought some this morning in Tesco (no links to Tesco other than my clubcard btw)

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By *69BANMan
over a year ago

Reading


"The steps you've described are essentially the same for any drug to be approved and are not unique to vaccines.

Given the huge scale of current worldwide effort, sooner or later Covid vaccines will become available. There are two main unknowns for any of these vaccines

1. How long will the vaccine provide immunity?

At one extreme there are vaccines where one dose gives you lifelong protection. At the other end there are vaccines which need frequent renewal.

2. How well will the vaccine protect against mutant forms of the virus?

Viruses mutate constantly, that's what they do. Any resistance will need to be carefully monitored.

Separately, there's the safety issue as no drug is 100% safe. However, vaccines typically do not have serious side effects compared to many other medicines.

While the clinical trials will give some indication, often the true value or risks of a drug can be determined only after it's approved and used by a lot more people.

"

To answer your second question, it will protect against mutations for SARS-2 because unless there is one that significantly changes a spike protein etc, then all mutations will still come under SARS-2. A significant enough change means it is no longer SARS-2, much like SARS and MERS are not this virus.

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By (user no longer on site)
over a year ago


"As long as it isn't mandatory, I have no problem with it.

There's already a rising figure of over a quarter of UK people who will refuse this vaccine.

Also Bill Gates has funded 750 million dollars towards this Oxford vaccine.

So 75 per cent will. That's a great place to start from.

Already down to 73% and falling.

So tragic that so many people have such a closed mind, when extensive global research hasn't even been completed yet! "

Very true, so many with a closed mind, I'm sure a lot of of this 73% will change their mind as they learn more.

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By (user no longer on site)
over a year ago


"As long as it isn't mandatory, I have no problem with it.

There's already a rising figure of over a quarter of UK people who will refuse this vaccine.

Also Bill Gates has funded 750 million dollars towards this Oxford vaccine.

Bill Gates has completely and utterly no link, financial of otherwise to the Oxford Vaccine!

Absolutely totally true. Bill Gates has no link financially or otherwise to the Oxford vaccine

The $750 million funding doesn't count.

The $750 dollars are for manufacturing and distribution not research. The gates foundation have given it so bill gates isn't going to profit from it anymore than the nhs or the british government are.

Bill Gates has completely and utterly no link, financial of otherwise to the Oxford Vaccine.

Just as I have no link, financially or otherwise to Weetabix. But I bought some this morning in Tesco (no links to Tesco other than my clubcard btw)"

Have you tried Tesco's own version of Weetabix? They're not bad

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By (user no longer on site)
over a year ago

Just like the people that tell me im stupid for asking legitimate questions lol. Just shows what you're up against.

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By *eddy and legsCouple
over a year ago

the wetlands

[Removed by poster at 24/07/20 19:05:27]

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By *iewMan
Forum Mod

over a year ago

Angus & Findhorn

Please do not post links directly on the thread that are not allowed. I have removed one and a reply that included it.

For reference:

Links to other sites

We have restrictions on where you can link to because otherwise people end up posting spam or links to places that host malware/spyware and it's bad for our users.

You can link to:

Any well recognised news site (bbc, times, telegraph, sun, cnn and all the rest)

Youtube

Lovehoney

Wikipedia

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By *hrista BellendWoman
over a year ago

surrounded by twinkly lights

I am not an anti vaxxer

But once I hear that it is being tested on quantities of people over the age of 50 and lasts more than 5 weeks before reinfection can occur I will be happier, but that's a while off yet.

I am also keeping a close eye on the Chinese vaccine results in the science papers as that looks promising for longer protection periods

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By (user no longer on site)
over a year ago


"I am not an anti vaxxer

But once I hear that it is being tested on quantities of people over the age of 50 and lasts more than 5 weeks before reinfection can occur I will be happier, but that's a while off yet.

I am also keeping a close eye on the Chinese vaccine results in the science papers as that looks promising for longer protection periods

"

Haha laughed at this one, Chinese tests haha they are more used to vaccinating their people to eradicate them.

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By *ljamMan
over a year ago

Edinburgh


"I am not an anti vaxxer

But once I hear that it is being tested on quantities of people over the age of 50 and lasts more than 5 weeks before reinfection can occur I will be happier, but that's a while off yet.

I am also keeping a close eye on the Chinese vaccine results in the science papers as that looks promising for longer protection periods

Haha laughed at this one, Chinese tests haha they are more used to vaccinating their people to eradicate them. "

Do you have any evidence for this ludicrous claim? Which incidentally wouldn't be very funny in the highly unlikely case it's true...

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By *ilth500Man
over a year ago

Merseyside

i think its fantastic we all dont think the same. i think its fantastic we have a choice in what drugs go into our own bodies and children's bodies. isnt it great we are allowed to make these decisions freely???

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By *naswingdressWoman
over a year ago

Manchester (she/her)

It's definitely promising, along with some others. I hope there'll be wide uptake, so we all protect each other.

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By *ljamMan
over a year ago

Edinburgh


"i think its fantastic we all dont think the same. i think its fantastic we have a choice in what drugs go into our own bodies and children's bodies. isnt it great we are allowed to make these decisions freely??? "

Mostly agree... but there's a duty of care when it comes to children. Anti-vax movement has led to a resurgence of some previously controlled and potentially very dangerous illnesses like measles and kids can be put at risk by the decisions of their parents.

But as has been said elsewhere, hopefully this or one of the other vaccines delivers on their early promise and our society gets a grip on this thing. I find the progress a remarkable source of optimism for humanity as a whole.

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By (user no longer on site)
over a year ago


"I am not an anti vaxxer

But once I hear that it is being tested on quantities of people over the age of 50 and lasts more than 5 weeks before reinfection can occur I will be happier, but that's a while off yet.

I am also keeping a close eye on the Chinese vaccine results in the science papers as that looks promising for longer protection periods

Haha laughed at this one, Chinese tests haha they are more used to vaccinating their people to eradicate them.

Do you have any evidence for this ludicrous claim? Which incidentally wouldn't be very funny in the highly unlikely case it's true..."

Maybe not by vaccinating but they do dispose of their unwanted population as they see fit

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By *hrista BellendWoman
over a year ago

surrounded by twinkly lights


"I am not an anti vaxxer

But once I hear that it is being tested on quantities of people over the age of 50 and lasts more than 5 weeks before reinfection can occur I will be happier, but that's a while off yet.

I am also keeping a close eye on the Chinese vaccine results in the science papers as that looks promising for longer protection periods

Haha laughed at this one, Chinese tests haha they are more used to vaccinating their people to eradicate them.

Do you have any evidence for this ludicrous claim? Which incidentally wouldn't be very funny in the highly unlikely case it's true..."

Google ad5-nCoV and have a read of the current science papers for ludicrous claims...

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By (user no longer on site)
over a year ago


"I am not an anti vaxxer

But once I hear that it is being tested on quantities of people over the age of 50 and lasts more than 5 weeks before reinfection can occur I will be happier, but that's a while off yet.

I am also keeping a close eye on the Chinese vaccine results in the science papers as that looks promising for longer protection periods

Haha laughed at this one, Chinese tests haha they are more used to vaccinating their people to eradicate them.

Do you have any evidence for this ludicrous claim? Which incidentally wouldn't be very funny in the highly unlikely case it's true...

Google ad5-nCoV and have a read of the current science papers for ludicrous claims..."

I hope if in the unlikely event that if some country does find a vaccine it is not going to be China.

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By *ljamMan
over a year ago

Edinburgh


"I am not an anti vaxxer

But once I hear that it is being tested on quantities of people over the age of 50 and lasts more than 5 weeks before reinfection can occur I will be happier, but that's a while off yet.

I am also keeping a close eye on the Chinese vaccine results in the science papers as that looks promising for longer protection periods

Haha laughed at this one, Chinese tests haha they are more used to vaccinating their people to eradicate them.

Do you have any evidence for this ludicrous claim? Which incidentally wouldn't be very funny in the highly unlikely case it's true...

Google ad5-nCoV and have a read of the current science papers for ludicrous claims..."

Sorry... what's the ludicrous bit? I've seen a series of articles and abstracts charting the development and testing of a vaccine which shows promise, from outlets such as the lancet and reuters.

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By *naswingdressWoman
over a year ago

Manchester (she/her)


"i think its fantastic we all dont think the same. i think its fantastic we have a choice in what drugs go into our own bodies and children's bodies. isnt it great we are allowed to make these decisions freely???

Mostly agree... but there's a duty of care when it comes to children. Anti-vax movement has led to a resurgence of some previously controlled and potentially very dangerous illnesses like measles and kids can be put at risk by the decisions of their parents.

But as has been said elsewhere, hopefully this or one of the other vaccines delivers on their early promise and our society gets a grip on this thing. I find the progress a remarkable source of optimism for humanity as a whole."

I think it's also a responsibility to wider society to vaccinate ourselves, to protect those who can't be for medical reasons.

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By *ilth500Man
over a year ago

Merseyside


"i think its fantastic we all dont think the same. i think its fantastic we have a choice in what drugs go into our own bodies and children's bodies. isnt it great we are allowed to make these decisions freely???

Mostly agree... but there's a duty of care when it comes to children. Anti-vax movement has led to a resurgence of some previously controlled and potentially very dangerous illnesses like measles and kids can be put at risk by the decisions of their parents.

But as has been said elsewhere, hopefully this or one of the other vaccines delivers on their early promise and our society gets a grip on this thing. I find the progress a remarkable source of optimism for humanity as a whole."

remember a certain 'pandemic' about 10yrs ago? well i refused my child that injection and hes leading a very very healthy active life. the human immune system is incredibly strong. ill be doing the same this time round too, my grandad, 92, never had a flu jab, still lives a active life. maybe my family are lucky and our genes and immune system are strong but i think ill pass on this 'duty of care' thing. youll probably point out the many deaths and stories of other people refusing vaccines/jabs and yes its tragic but im happy that we live in a society where we can think for ourselves and make our own decisions. i dont in any way look down on anyone's choice to take the vaccine/jab, but my choice is to not

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By *uriousTwosomeCouple
over a year ago

Manchester

I await the ‘I am Legend’ apocalypse!!

But on the basis we need to fuck again, and ‘someone’ wants a BBC gangbang, then we are definitely gonna have the vaccine!!

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By (user no longer on site)
over a year ago


"I am not an anti vaxxer

But once I hear that it is being tested on quantities of people over the age of 50 and lasts more than 5 weeks before reinfection can occur I will be happier, but that's a while off yet.

I am also keeping a close eye on the Chinese vaccine results in the science papers as that looks promising for longer protection periods

Haha laughed at this one, Chinese tests haha they are more used to vaccinating their people to eradicate them.

Do you have any evidence for this ludicrous claim? Which incidentally wouldn't be very funny in the highly unlikely case it's true...

Google ad5-nCoV and have a read of the current science papers for ludicrous claims...

Sorry... what's the ludicrous bit? I've seen a series of articles and abstracts charting the development and testing of a vaccine which shows promise, from outlets such as the lancet and reuters."

Lots of tests and outlets sound off optimism that there is hope and hopefully there will be but the stark reality is that 95% of vaccine tests fail after launch and respiratory illness are very hard to cure. They have not found a cure for influenza,they can treat it and prevent it to some extent but this common flu has been with us forever and no vaccine has been forth coming so the prospect of a respiroty vaccine being found for a much more serious strain is remote. The fact that countries around the world have invested huge amounts to try and find a vaccine should put paid to conspiracy theorists and make them realise that this is very real and the fact that Boris has invested huge amounts of money buying up these not yet fully developed or tested vaccine means jack shit. He is just covering his back in the unlikely event that one of them will work

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By *naswingdressWoman
over a year ago

Manchester (she/her)

Hopefully we'll see something from the trials funded from the US Operation Warp Speed too. The mRNA Moderna vaccine and there's a similar Pfizer vaccine

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By *abioMan
over a year ago

Newcastle and Gateshead


"Hopefully we'll see something from the trials funded from the US Operation Warp Speed too. The mRNA Moderna vaccine and there's a similar Pfizer vaccine"

the moderma phase 1 trials were only done on 35 people..... its nowhere near as tested so far as the oxford vaccine....

i'll put what i did in the other thread because i think its really relevant to conversation.... plus a few bracketed additions

although it is good news thats oxford pasts its stage 1 and 2 phase trails.... there are bits in the report that scream "slow down" with some of the hype...

1) there are some side effects but not serious enough to stop the trials.... (this was the same for both the oxford and moderma trials)

2) most people were treated at the low single dose... which means that although they did produce antibodies, it was a low rate....

3) it was only at the higher double dose rate they found the higher antibodies and the "fight back cells".. but only a dozen people out of the 1000 person trial were given the "double dose"

(in the moderma trail 15 were given a low dose,100mg. 10 a medium dose,250mg. and 10 a high dose,500mg..... trey found the higher the dose the more extreme the side effects!)

so they still really need to find a correct dosage in both cases (although moderma for the time being are going to concentrate on the 250mg dosage) plus if the managable side effects are more prevelant if taken at the higher doses....

its a good start... now see what they do with the much bigger phase 3 trial

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By *naswingdressWoman
over a year ago

Manchester (she/her)

Oh definitely. I'm not saying "it's ready to go, sign me up", I'm saying "it's potentially promising from what I've heard, it's good that the investment is there" sort of thing. There are some contenders. And I gather that antibody response is not black and white.

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By *lirty and funMan
over a year ago

Redditch

All definitely good news on the Oxford vaccine.

I actually read an article on the level of antibodies and time of effectiveness and this was positive reading too.

Ie; the antibody levels do decrease but slowly over time...but the T cell memory would stay for a long time (stays in the bone marrow) and would make new antibodies quicker and more effective anyway.

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By *naswingdressWoman
over a year ago

Manchester (she/her)


"All definitely good news on the Oxford vaccine.

I actually read an article on the level of antibodies and time of effectiveness and this was positive reading too.

Ie; the antibody levels do decrease but slowly over time...but the T cell memory would stay for a long time (stays in the bone marrow) and would make new antibodies quicker and more effective anyway. "

My understanding is that the relationship between antibodies and T cell immunity isn't entirely understood yet, but both may play a role here (but antibodies waning is a normal immunological response because our bodies need to do other things)

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By *lirty and funMan
over a year ago

Redditch


"All definitely good news on the Oxford vaccine.

I actually read an article on the level of antibodies and time of effectiveness and this was positive reading too.

Ie; the antibody levels do decrease but slowly over time...but the T cell memory would stay for a long time (stays in the bone marrow) and would make new antibodies quicker and more effective anyway.

My understanding is that the relationship between antibodies and T cell immunity isn't entirely understood yet, but both may play a role here (but antibodies waning is a normal immunological response because our bodies need to do other things)"

I think you are probably right...but then I am no expert.

I am an expert on spotting a fit body mind! x

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By *naswingdressWoman
over a year ago

Manchester (she/her)


"All definitely good news on the Oxford vaccine.

I actually read an article on the level of antibodies and time of effectiveness and this was positive reading too.

Ie; the antibody levels do decrease but slowly over time...but the T cell memory would stay for a long time (stays in the bone marrow) and would make new antibodies quicker and more effective anyway.

My understanding is that the relationship between antibodies and T cell immunity isn't entirely understood yet, but both may play a role here (but antibodies waning is a normal immunological response because our bodies need to do other things)

I think you are probably right...but then I am no expert.

I am an expert on spotting a fit body mind! x"

Appreciate it

I'm not an expert by a long shot... I'm good at finding reliable sources. Been listening to science communicators on this since March. I pick up bits and pieces

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By *hrista BellendWoman
over a year ago

surrounded by twinkly lights


"I am not an anti vaxxer

But once I hear that it is being tested on quantities of people over the age of 50 and lasts more than 5 weeks before reinfection can occur I will be happier, but that's a while off yet.

I am also keeping a close eye on the Chinese vaccine results in the science papers as that looks promising for longer protection periods

Haha laughed at this one, Chinese tests haha they are more used to vaccinating their people to eradicate them.

Do you have any evidence for this ludicrous claim? Which incidentally wouldn't be very funny in the highly unlikely case it's true...

Google ad5-nCoV and have a read of the current science papers for ludicrous claims...

Sorry... what's the ludicrous bit? I've seen a series of articles and abstracts charting the development and testing of a vaccine which shows promise, from outlets such as the lancet and reuters."

Apologies. I misread your comment as a reply to my post, rather than to the eradication comment

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By *adyGardenWoman
over a year ago

LONDON (se)

I have no intention of taking a vaccine that has taken so little time to produce. It normally takes around 14yrs to produce and test a vaccine. No way will I put something in mine or my children's bodies that haven't been so vigorously tested.

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By *69BANMan
over a year ago

Reading


"I am not an anti vaxxer

But once I hear that it is being tested on quantities of people over the age of 50 and lasts more than 5 weeks before reinfection can occur I will be happier, but that's a while off yet.

I am also keeping a close eye on the Chinese vaccine results in the science papers as that looks promising for longer protection periods

Haha laughed at this one, Chinese tests haha they are more used to vaccinating their people to eradicate them.

Do you have any evidence for this ludicrous claim? Which incidentally wouldn't be very funny in the highly unlikely case it's true...

Google ad5-nCoV and have a read of the current science papers for ludicrous claims...

Sorry... what's the ludicrous bit? I've seen a series of articles and abstracts charting the development and testing of a vaccine which shows promise, from outlets such as the lancet and reuters.

Lots of tests and outlets sound off optimism that there is hope and hopefully there will be but the stark reality is that 95% of vaccine tests fail after launch and respiratory illness are very hard to cure. They have not found a cure for influenza,they can treat it and prevent it to some extent but this common flu has been with us forever and no vaccine has been forth coming so the prospect of a respiroty vaccine being found for a much more serious strain is remote. The fact that countries around the world have invested huge amounts to try and find a vaccine should put paid to conspiracy theorists and make them realise that this is very real and the fact that Boris has invested huge amounts of money buying up these not yet fully developed or tested vaccine means jack shit. He is just covering his back in the unlikely event that one of them will work "

I don't think you understand what you're trying to say, you're getting mixed up and conflating different viruses. The 'cure' for influenza is to get vaccinated and increase herd immunity, so yes there are vaccines for flu. SARS-2 is not the flu. But the prospect of finding a viable vaccine is likely because the body has an immune response to it, so we know creating a vaccine is very much possible.

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By *ilth500Man
over a year ago

Merseyside


"I have no intention of taking a vaccine that has taken so little time to produce. It normally takes around 14yrs to produce and test a vaccine. No way will I put something in mine or my children's bodies that haven't been so vigorously tested. "

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By (user no longer on site)
over a year ago


"I have no intention of taking a vaccine that has taken so little time to produce. It normally takes around 14yrs to produce and test a vaccine. No way will I put something in mine or my children's bodies that haven't been so vigorously tested. "

Which would be understandable if that was actually the case, but it isn't.

The oxford vaccine has been around for years has been proven to be safe they have just adapted it for Covid. That is the reason that Astra Zeneca have invested in producing the vaccine early.

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By *moothman2000Man
over a year ago

Leicestershire


"I have no intention of taking a vaccine that has taken so little time to produce. It normally takes around 14yrs to produce and test a vaccine. No way will I put something in mine or my children's bodies that haven't been so vigorously tested. "

If that's true, how do we get a different flu vaccine every year?

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By *naswingdressWoman
over a year ago

Manchester (she/her)

The time thing is a red herring. The question is whether the studies are rigorous in ensuring safety and efficacy.

That data doesn't exist, but I'm sure will be gone over extensively by those with the qualifications to understand it.

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By *adyGardenWoman
over a year ago

LONDON (se)


"I have no intention of taking a vaccine that has taken so little time to produce. It normally takes around 14yrs to produce and test a vaccine. No way will I put something in mine or my children's bodies that haven't been so vigorously tested.

If that's true, how do we get a different flu vaccine every year?"

I'm not convinced it is different every year. The flu has been around forever so more is known about it and vaccines adapted not different.

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By (user no longer on site)
over a year ago


"I have no intention of taking a vaccine that has taken so little time to produce. It normally takes around 14yrs to produce and test a vaccine. No way will I put something in mine or my children's bodies that haven't been so vigorously tested.

If that's true, how do we get a different flu vaccine every year?

I'm not convinced it is different every year. The flu has been around forever so more is known about it and vaccines adapted not different. "

Its different strains of flu every year.

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By *naswingdressWoman
over a year ago

Manchester (she/her)


"I have no intention of taking a vaccine that has taken so little time to produce. It normally takes around 14yrs to produce and test a vaccine. No way will I put something in mine or my children's bodies that haven't been so vigorously tested.

If that's true, how do we get a different flu vaccine every year?

I'm not convinced it is different every year. The flu has been around forever so more is known about it and vaccines adapted not different. "

Some of the Covid-19 vaccines are adapted based on existing technology.

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By *moothman2000Man
over a year ago

Leicestershire


"

I'm not convinced it is different every year. The flu has been around forever so more is known about it and vaccines adapted not different. "

At what point does adapted become different?

I'm absolutely not qualified, but my rudimentary understanding has been that the current years flu vaccine is based on last years flu virus with a likely evolution, based on historical patterns, built in.

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By (user no longer on site)
over a year ago


"I have no intention of taking a vaccine that has taken so little time to produce. It normally takes around 14yrs to produce and test a vaccine. No way will I put something in mine or my children's bodies that haven't been so vigorously tested. "

Very sensible

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By (user no longer on site)
over a year ago

[Removed by poster at 25/07/20 13:52:39]

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By (user no longer on site)
over a year ago


"I am not an anti vaxxer

But once I hear that it is being tested on quantities of people over the age of 50 and lasts more than 5 weeks before reinfection can occur I will be happier, but that's a while off yet.

I am also keeping a close eye on the Chinese vaccine results in the science papers as that looks promising for longer protection periods

Haha laughed at this one, Chinese tests haha they are more used to vaccinating their people to eradicate them.

Do you have any evidence for this ludicrous claim? Which incidentally wouldn't be very funny in the highly unlikely case it's true...

Google ad5-nCoV and have a read of the current science papers for ludicrous claims...

Sorry... what's the ludicrous bit? I've seen a series of articles and abstracts charting the development and testing of a vaccine which shows promise, from outlets such as the lancet and reuters.

Lots of tests and outlets sound off optimism that there is hope and hopefully there will be but the stark reality is that 95% of vaccine tests fail after launch and respiratory illness are very hard to cure. They have not found a cure for influenza,they can treat it and prevent it to some extent but this common flu has been with us forever and no vaccine has been forth coming so the prospect of a respiroty vaccine being found for a much more serious strain is remote. The fact that countries around the world have invested huge amounts to try and find a vaccine should put paid to conspiracy theorists and make them realise that this is very real and the fact that Boris has invested huge amounts of money buying up these not yet fully developed or tested vaccine means jack shit. He is just covering his back in the unlikely event that one of them will work

I don't think you understand what you're trying to say, you're getting mixed up and conflating different viruses. The 'cure' for influenza is to get vaccinated and increase herd immunity, so yes there are vaccines for flu. SARS-2 is not the flu. But the prospect of finding a viable vaccine is likely because the body has an immune response to it, so we know creating a vaccine is very much possible. "

I fully understand what I was saying. There is not a vaccine to cure you from getting Influenza, Aids, Sars etc:. There are preventitive measures and they work well to an extent but I don't think anyone should pin their hopes on finding something that can eradicate this virus not in the next few years anyway

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